Spending 220 days in space, Pettit and his crewmates Ovchinin and Vagner orbited the Earth 3520 times and completed a journey of 93.3 million miles over the course of their mission.
It was the fourth spaceflight for Pettit, who has logged more than 18 months in orbit throughout his 29-year career.
The trio touched down in a remote area southeast of Kazakhstan after undocking from the space station just over three hours earlier.
Nasa images of the landing showed the small capsule parachuting down to Earth with the sunrise as a backdrop.
The astronauts gave thumbs-up gestures as rescuers carried them from the spacecraft to an inflatable medical tent.
Despite looking a little worse for wear as he was pulled from the vessel, Pettit was “doing well and in the range of what is expected for him following return to Earth”, Nasa said in a statement.
He was then set to fly to the Kazakh city of Karaganda before boarding a NASA plane to the agency’s Johnson Space Center in Texas.
The astronauts spent their time on the ISS researching areas such as water sanitization technology, plant growth in various conditions and fire behavior in microgravity, NASA said.
The trio’s seven-month trip was just short of the nine months that NASA astronauts Butch Wilmore and Suni Williams unexpectedly spent stuck on the orbital lab after the spacecraft they were testing suffered technical issues and was deemed unfit to fly them back to Earth.
Space is one of the final areas of US-Russia cooperation amid an almost complete breakdown in relations between Moscow and Washington over the Ukraine conflict.
– Agence France-Presse